Upstream Bio, Inc.

UPB· NASDAQ· Health Care· Pharmaceuticals, Biotechnology & Life Sciences

$3.35-1.61%

2026-11-02

Financials

Valuation Metrics

Upstream Bio, Inc.'s Market Cap is $183M. At end of 2025 it was $1.46B. Ranked #2998 of 3,118 in US market (top 96%), #1373 of 1,474 on NASDAQ (top 93%), #249 of 265 in Pharmaceuticals, Biotechnology & Life Sciences (top 94%) by Market Cap.

Investment Metrics(as of 2026-11-02)

Metric	Value	Rank
Size
Market Cap	$183M	US#2,998/3,118 Sec#249/265
Revenue	$3M	US#2,828/3,118 Sec#181/265
Net Income	$-157M	US—/3,118 Sec—/265
Total Assets	$281M	US#2,918/3,118 Sec#214/265
Net Assets	$271M	US#2,558/3,118 Sec#159/265
Value
P/B	0.67x	US#174/3,118 Sec#8/265
P/S	57.81x	US#2,926/3,118 Sec#171/265
FCF Yield	-74.68%	US—/3,118 Sec—/265
Profitability
ROE	-57.76%	US#2,702/3,118 Sec#169/265
ROA	-55.66%	US#3,000/3,118 Sec#225/265
Op. Margin	-5382.65%	US#2,833/3,118 Sec#179/265
Revenue Growth	15.97%	US#855/3,118 Sec#81/265
Financial Health
Debt Ratio	3.77%	US#32/3,118 Sec#9/265
Total Debt	$954000.00	US#2,965/3,118 Sec#241/265
FCF	$-136M	US#2,699/3,118 Sec#172/265
Cash	$79M	US#2,345/3,118 Sec#191/265
Current Ratio	27.99x	US#83/3,118 Sec#12/265
Performance
1Y Return	-87.02%	US#3,104/3,118 Sec#260/265
1M Return	-33.43%	US#3,037/3,118 Sec#255/265
From 52W High	-90.04%	US#3,101/3,118 Sec#259/265
1Y MDD	-91.60%	US#3,113/3,118 Sec#261/265
Trading
Volume	862,488 shares	US#1,549/3,118 Sec#147/265
Trading Value	$3M	US#2,757/3,118 Sec#224/265
Per Share
EPS	$-2.88	US—/3,118 Sec—/265
BPS	$4.98	US#2,278/3,118 Sec#128/265