Upstream Bio, Inc.

UPB· NASDAQ· Health Care· Pharmaceuticals, Biotechnology & Life Sciences

$3.35-1.61%

2026-11-02

Financials

Valuation Metrics

Upstream Bio, Inc.'s Market Cap is $183M. At end of 2025 it was $1.46B. Ranked #3006 of 3,116 in US market (top 96%), #1380 of 1,472 on NASDAQ (top 94%), #250 of 265 in Pharmaceuticals, Biotechnology & Life Sciences (top 94%) by Market Cap.

Investment Metrics(as of 2026-11-02)

Metric	Value	Rank
Size
Market Cap	$183M	US#3,006/3,116 Sec#250/265
Revenue	$3M	US#2,829/3,116 Sec#181/265
Net Income	$-157M	US—/3,116 Sec—/265
Total Assets	$281M	US#2,917/3,116 Sec#213/265
Net Assets	$271M	US#2,556/3,116 Sec#159/265
Value
P/B	0.67x	US#156/3,116 Sec#5/265
P/S	57.81x	US#2,922/3,116 Sec#168/265
FCF Yield	-74.68%	US—/3,116 Sec—/265
Profitability
ROE	-57.76%	US#2,702/3,116 Sec#169/265
ROA	-55.66%	US#3,001/3,116 Sec#225/265
Op. Margin	-5382.65%	US#2,834/3,116 Sec#179/265
Revenue Growth	15.97%	US#847/3,116 Sec#81/265
Financial Health
Debt Ratio	3.77%	US#32/3,116 Sec#9/265
Total Debt	$954000.00	US#2,970/3,116 Sec#242/265
FCF	$-136M	US#2,703/3,116 Sec#172/265
Cash	$79M	US#2,346/3,116 Sec#191/265
Current Ratio	27.99x	US#82/3,116 Sec#12/265
Performance
1Y Return	-87.02%	US#3,104/3,116 Sec#260/265
1M Return	-33.43%	US#3,059/3,116 Sec#259/265
From 52W High	-90.04%	US#3,106/3,116 Sec#261/265
1Y MDD	-91.60%	US#3,112/3,116 Sec#261/265
Trading
Volume	862,488 shares	US#1,346/3,116 Sec#132/265
Trading Value	$3M	US#2,734/3,116 Sec#223/265
Per Share
EPS	$-2.88	US—/3,116 Sec—/265
BPS	$4.98	US#2,276/3,116 Sec#128/265