Upstream Bio, Inc.

UPB· NASDAQ· Health Care· Pharmaceuticals, Biotechnology & Life Sciences

$5.34+0.56%

2026-09-18

Financials

Valuation Metrics

Upstream Bio, Inc.'s Market Cap is $291M. At end of 2025 it was $1.46B. Ranked #2953 of 3,121 in US market (top 95%), #1334 of 1,463 on NASDAQ (top 91%), #244 of 266 in Pharmaceuticals, Biotechnology & Life Sciences (top 92%) by Market Cap.

Investment Metrics(as of 2026-09-18)

Metric	Value	Rank
Size
Market Cap	$291M	US#2,953/3,121 Sec#244/266
Revenue	$3M	US#2,860/3,121 Sec#184/266
Net Income	$-157M	US—/3,121 Sec—/266
Total Assets	$281M	US#2,930/3,121 Sec#216/266
Net Assets	$271M	US#2,572/3,121 Sec#162/266
Value
P/B	1.07x	US#450/3,121 Sec#15/266
P/S	92.02x	US#2,942/3,121 Sec#175/266
FCF Yield	-46.92%	US—/3,121 Sec—/266
Profitability
ROE	-57.76%	US#2,712/3,121 Sec#168/266
ROA	-55.66%	US#3,007/3,121 Sec#224/266
Op. Margin	-5382.65%	US#2,862/3,121 Sec#182/266
Revenue Growth	15.97%	US#866/3,121 Sec#83/266
Financial Health
Debt Ratio	3.77%	US#31/3,121 Sec#9/266
Total Debt	$954000.00	US#2,987/3,121 Sec#245/266
FCF	$-136M	US#2,702/3,121 Sec#170/266
Cash	$79M	US#2,352/3,121 Sec#192/266
Current Ratio	27.99x	US#86/3,121 Sec#12/266
Performance
1Y Return	-69.08%	US#3,052/3,121 Sec#255/266
1M Return	-28.99%	US#3,008/3,121 Sec#246/266
From 52W High	-84.14%	US#3,102/3,121 Sec#264/266
1Y MDD	-83.71%	US#3,087/3,121 Sec#259/266
Trading
Volume	815,072 shares	US#1,989/3,121 Sec#208/266
Trading Value	$4M	US#2,829/3,121 Sec#241/266
Per Share
EPS	$-2.88	US—/3,121 Sec—/266
BPS	$4.98	US#2,287/3,121 Sec#130/266