Spyre Therapeutics, Inc.

SYRE· NASDAQ· Health Care· Pharmaceuticals, Biotechnology & Life Sciences

$94.93-3.46%

2026-08-03

Financials

Valuation Metrics

Spyre Therapeutics, Inc.'s Market Cap is $8.24B. At end of 2025 it was $11.34B. Ranked #1060 of 3,112 in US market (top 34%), #347 of 1,445 on NASDAQ (top 24%), #56 of 269 in Pharmaceuticals, Biotechnology & Life Sciences (top 21%) by Market Cap.

Investment Metrics(as of 2026-08-03)

Metric	Value	Rank
Size
Market Cap	$8.24B	US#1,060/3,112 Sec#56/269
Revenue	$90M	US#2,799/3,112 Sec#129/269
Net Income	$-179M	US—/3,112 Sec—/269
Total Assets	$764M	US#2,557/3,112 Sec#111/269
Net Assets	$671M	US#2,046/3,112 Sec#80/269
Value
P/B	12.29x	US#2,680/3,112 Sec#213/269
P/S	91.10x	US#2,904/3,112 Sec#178/269
FCF Yield	-2.25%	US—/3,112 Sec—/269
Profitability
ROE	-26.75%	US#2,585/3,112 Sec#117/269
ROA	-23.49%	US#2,815/3,112 Sec#139/269
Op. Margin	-255.97%	US#2,871/3,112 Sec#146/269
Financial Health
Debt Ratio	13.88%	US#160/3,112 Sec#68/269
Total Debt	$0.00	US—/3,112 Sec—/269
FCF	$-186M	US#2,721/3,112 Sec#212/269
Cash	$97M	US#2,230/3,112 Sec#180/269
Current Ratio	8.97x	US#277/3,112 Sec#89/269
Performance
1Y Return	483.83%	US#15/3,112 Sec#8/269
1M Return	9.58%	US#558/3,112 Sec#25/269
From 52W High	-9.67%	US#1,012/3,112 Sec#48/269
1Y MDD	-20.15%	US#688/3,112 Sec#25/269
Trading
Volume	799,736 shares	US#1,681/3,112 Sec#157/269
Trading Value	$77M	US#1,069/3,112 Sec#64/269
Per Share
EPS	$-0.45	US—/3,112 Sec—/269
BPS	$2.07	US#2,498/3,112 Sec#175/269