Protagonist Therapeutics, Inc.
Financials
Valuation Metrics
Protagonist Therapeutics, Inc.'s Market Cap is $8.97B. At end of 2025 it was $5.55B. Ranked #956 of 3,116 in US market (top 31%), #308 of 1,472 on NASDAQ (top 21%), #47 of 265 in Pharmaceuticals, Biotechnology & Life Sciences (top 18%) by Market Cap.
Investment Metrics(as of 2026-11-02)
| Metric | Value | Rank |
|---|---|---|
| Size | ||
| Market Cap | $8.97B | US#956/3,116 Sec#47/265 |
| Revenue | $282M | US#2,452/3,116 Sec#99/265 |
| Net Income | $83M | US#1,686/3,116 Sec#57/265 |
| Total Assets | $886M | US#2,524/3,116 Sec#112/265 |
| Net Assets | $842M | US#1,873/3,116 Sec#76/265 |
| Employees | 132 | US#2,564/3,116 Sec#157/265 |
| Value | ||
| P/E | 108.23x | US#2,109/3,116 Sec#66/265 |
| P/B | 10.66x | US#2,650/3,116 Sec#197/265 |
| PEG | 1.82x | US#1,007/3,116 Sec#28/265 |
| P/S | 31.82x | US#2,890/3,116 Sec#157/265 |
| EV/EBITDA | 100.17x | US#2,427/3,116 Sec#80/265 |
| FCF Yield | 1.47% | US#2,108/3,116 Sec#72/265 |
| Profitability | ||
| ROE | 9.85% | US#1,382/3,116 Sec#47/265 |
| ROA | 9.36% | US#517/3,116 Sec#36/265 |
| Op. Margin | 20.69% | US#856/3,116 Sec#41/265 |
| Revenue Growth | 34.81% | US#345/3,116 Sec#55/265 |
| Earnings Growth | 59.32% | US#430/3,116 Sec#20/265 |
| Financial Health | ||
| Debt Ratio | 5.23% | US#38/3,116 Sec#13/265 |
| Total Debt | $9M | US#2,833/3,116 Sec#200/265 |
| FCF | $132M | US#1,608/3,116 Sec#57/265 |
| Cash | $420M | US#1,177/3,116 Sec#66/265 |
| Current Ratio | 21.71x | US#109/3,116 Sec#21/265 |
| Net Debt/EBITDA | -4.81x | US#78/3,116 Sec#5/265 |
| Performance | ||
| 1Y Return | 77.47% | US#209/3,116 Sec#47/265 |
| 1M Return | -0.38% | US#1,597/3,116 Sec#104/265 |
| From 52W High | -13.23% | US#865/3,116 Sec#49/265 |
| 1Y MDD | -18.83% | US#561/3,116 Sec#17/265 |
| Trading | ||
| Volume | 305,623 shares | US#2,376/3,116 Sec#227/265 |
| Trading Value | $43M | US#1,364/3,116 Sec#101/265 |
| Per Share | ||
| EPS | $1.29 | US#1,580/3,116 Sec#45/265 |
| BPS | $13.09 | US#1,638/3,116 Sec#53/265 |
Company Info
Protagonist Therapeutics, Inc. operates as a discovery and development company in the United States. It develops Icotyde, a first-in-class investigational targeted oral peptide for the treatment of adults and pediatric patients 12 years of age and older with moderate-to-severe plaque psoriasis; and Rusfertide, a first-in-class investigational injectable mimetic of the natural hormone hepcidin in Phase 3 development for the treatment of the rare blood disorder polycythemia vera. The company is also developing PN-881, a potential best-in-class oral peptide IL-17 antagonist, for the treatment of immune-mediated skin diseases in Phase 1 clinical trials; PN-477 and PN-458, which are development candidates for the treatment of obesity; PN-8047, an orally administered hepcidin functional mimetic small molecule; L-4R alpha antagonist for the treatment of atopic dermatitis and moderate-to-severe asthma; and amylinR-based oral and subcutaneous mono- and poly-agonists for the treatment of obesity. Protagonist Therapeutics, Inc. was incorporated in 2006 and is headquartered in Newark, California.