Protagonist Therapeutics, Inc.
Financials
Valuation Metrics
Protagonist Therapeutics, Inc.'s Market Cap is $9.24B. At end of 2025 it was $5.55B. Ranked #971 of 3,121 in US market (top 31%), #316 of 1,463 on NASDAQ (top 22%), #49 of 266 in Pharmaceuticals, Biotechnology & Life Sciences (top 18%) by Market Cap.
Investment Metrics(as of 2026-09-18)
| Metric | Value | Rank |
|---|---|---|
| Size | ||
| Market Cap | $9.24B | US#971/3,121 Sec#49/266 |
| Revenue | $282M | US#2,483/3,121 Sec#99/266 |
| Net Income | $83M | US#1,696/3,121 Sec#54/266 |
| Total Assets | $886M | US#2,533/3,121 Sec#113/266 |
| Net Assets | $842M | US#1,883/3,121 Sec#77/266 |
| Employees | 132 | US#2,579/3,121 Sec#159/266 |
| Value | ||
| P/E | 111.47x | US#2,121/3,121 Sec#65/266 |
| P/B | 10.98x | US#2,648/3,121 Sec#200/266 |
| PEG | 1.88x | US#1,029/3,121 Sec#29/266 |
| P/S | 32.77x | US#2,890/3,121 Sec#154/266 |
| EV/EBITDA | 103.30x | US#2,441/3,121 Sec#81/266 |
| FCF Yield | 1.43% | US#2,124/3,121 Sec#71/266 |
| Profitability | ||
| ROE | 9.85% | US#1,390/3,121 Sec#47/266 |
| ROA | 9.36% | US#521/3,121 Sec#35/266 |
| Op. Margin | 20.69% | US#874/3,121 Sec#39/266 |
| Revenue Growth | 34.81% | US#355/3,121 Sec#57/266 |
| Earnings Growth | 59.32% | US#453/3,121 Sec#21/266 |
| Financial Health | ||
| Debt Ratio | 5.23% | US#39/3,121 Sec#13/266 |
| Total Debt | $9M | US#2,844/3,121 Sec#202/266 |
| FCF | $132M | US#1,611/3,121 Sec#56/266 |
| Cash | $420M | US#1,183/3,121 Sec#65/266 |
| Current Ratio | 21.71x | US#112/3,121 Sec#22/266 |
| Net Debt/EBITDA | -4.81x | US#77/3,121 Sec#5/266 |
| Performance | ||
| 1Y Return | 142.65% | US#118/3,121 Sec#47/266 |
| 1M Return | -8.67% | US#2,291/3,121 Sec#172/266 |
| From 52W High | -10.64% | US#768/3,121 Sec#54/266 |
| 1Y MDD | -16.38% | US#434/3,121 Sec#12/266 |
| Trading | ||
| Volume | 548,450 shares | US#1,937/3,121 Sec#201/266 |
| Trading Value | $79M | US#968/3,121 Sec#67/266 |
| Per Share | ||
| EPS | $1.29 | US#1,589/3,121 Sec#42/266 |
| BPS | $13.09 | US#1,647/3,121 Sec#54/266 |
Company Info
Protagonist Therapeutics, Inc. operates as a discovery and development company in the United States. It develops Icotyde, a first-in-class investigational targeted oral peptide for the treatment of adults and pediatric patients 12 years of age and older with moderate-to-severe plaque psoriasis; and Rusfertide, a first-in-class investigational injectable mimetic of the natural hormone hepcidin in Phase 3 development for the treatment of the rare blood disorder polycythemia vera. The company is also developing PN-881, a potential best-in-class oral peptide IL-17 antagonist, for the treatment of immune-mediated skin diseases in Phase 1 clinical trials; PN-477 and PN-458, which are development candidates for the treatment of obesity; PN-8047, an orally administered hepcidin functional mimetic small molecule; L-4R alpha antagonist for the treatment of atopic dermatitis and moderate-to-severe asthma; and amylinR-based oral and subcutaneous mono- and poly-agonists for the treatment of obesity. Protagonist Therapeutics, Inc. was incorporated in 2006 and is headquartered in Newark, California.